Effect of Imipramine and Ect on Platelet Mao Activity in Depressives
نویسندگان
چکیده
Platelet monoamine Oxidase (MAO) activity was estimated in 30 depressed patients treated with Imipramine or EGT over a period of 5 weeks and pretreatment and post treatment values were compared. Imipramine and ECT caused significant reduction of platelet MAO, which after 7 days washout period comes to the pretreatment level while subjects clinical status l remained unchanged. The percentage blockade in platelet MAO values by Imipramine and ECT was 51.40±13.43 and 34.73±24.27 respectively.
منابع مشابه
Active Platelet 5-ht Uptake in Depressives Treated with Impramine and Ect
Several studies have reported decreased platelet 5-HT uptake in patients of major depression. The present study was undertaken with the aim to study the active platelet 5-HT uptake in depressed patients and effect of treatment with imipramine/ECT on platelet 5-HT uptake in these patients. 30 patients of major depression and equal number of age and sex-matched controls were included in the study...
متن کاملPost Dexamethasone Plasma Cortisol Levels in Depressives Treated with Imipramine and Electroconvulsive Therapy5
Sixty patients of endogenous depression and thirty normal controls were studied to find out the relationship of post dexamethasone plasma Cortisol levels (PDPC) and clinical improvement of endogenous depression inpatients treated with electroconvulsive therapy and imipramine. The PDPC levels in both the group of patients showed significant decrease with clinical improvement (Pre and post treatm...
متن کاملThis Excerpt Is from Chapter 104 Complementary and Alternative Treatments in Psychiatry
relaxation, and give many health benefits. However varied, its many techniques constitute a psychophysiological therapy which invites applications to psychiatric disorders. For reviews of yoga philosophy, techniques, neurophysiological findings, and studies in anxiety, depression, OCD (Shannahoff-Khalsa et al. 1999), and epilepsy, see Yardi (Kraft et al. 2001) and Becker (Becker, 2000). Janakir...
متن کاملEffect of chlorpromazine, imipramine and lithium on MAO-A and MAO-B activity in rat brain mitochondria.
Drugs with efficacy in psychiatric disorders affect the function of central neurotransmitter amines, which are inactivated primarily by monoamine oxidase (MAO). Effect of these drugs on the two types of MAO (MAO-A and MAO-B) has been studied in rat brain. The result showed that chlorpromazine (CPZ) and imipramine (IMI) at concentrations of 1x10(-2), 5x10(-3) and 2.5x10(-3) M inhibited rat brain...
متن کاملNorepinephrine and Serotonin Metabolism and Clinical Response to Combined Imipramine and Amitriptyline Therapy in Depression
The present study was aimed to find out the alteration of NE and 5HT systems in depression, if so in the same direction or not and to find out the clinical response to combined therapy of Imipramine and Amitriptyline, both tricyclic antidepressants. The study group consisted of 39 depressives as defined by I. C. D. 9 and 17 normal controls. Hamilton Depression Rating Scale was used to assess th...
متن کامل